Bulletin of Semashko National Research Institute of Public HealthBulletin of Semashko National Research Institute of Public Health2415-84102415-8429FSSBI «N.A. Semashko National Research Institute of Public Health»1509Научная статьяANTIVIRAL DRUGS: FROM CREATION TO THE PRESENTTelnovaE. Atelnovaea@yandex.ruShchepinV. Oshchepin131@mail.ruZagoruychenkoA. Azagoranna@mail.ruN.A. Semashko National Research Institute of Public Health, Moscow, Russian Federation18122020410811908042022Copyright © 2020,2020Every year, according to the World Health Organization, infectious diseases account for approximately 25% of the total number of fatal diseases. Infections remain one of the leading causes of death. In this regard, the discovery of viruses, and then the appearance of drugs for the treatment and prevention of diseases caused by viruses, is of great importance for all of humanity. All this served as a serious impetus for studying the structure of the virus, as well as the processes of their reproduction in the body of the "host", researching their distribution and prevention. The review talks about the history of the discovery of viruses, as well as the history of the creation of modern antiviral drugs. Until recently, this issue has received little attention. Due to the special activity of various viral infections such as AIDS, hepatitis, herpes, as well as influenza, pneumonia, and now also COVID-19, the late XXth and early XXIst centuries are characterized by the rapid development of virology, immunology, microbiology, as well as biochemistry, biotechnology, genetic engineering and other sciences. Thanks to this, it was possible to synthesize many new drugs for the prevention, diagnosis and treatment of viral diseases belonging to various pharmacological groups. The authors of the article studied the modern arsenal of antiviral drugs, the principle of their action and use, classification, structure; considered the features of the virus as a pharmacodynamic target, the problems of pharmacotherapy of viral infections.COVID-19antiviral drugsinfectious diseasesvirusesCOVID-19vaccinesпротивовирусные препаратыинфекционные заболеваниявирусывакцины1.История открытия вирусов. Известные микробиологи. - URL:https://fb.ru/article/357518/istoriya-otkryitiya-virusov-izvestnyie-mikrobiologi2.Кузнецов Н.И. Современные принципы противовирусной терапии гепатита С. Современный взгляд на проблему / Н.И. Кузнецов, Е.С. Романова, Г.Ю. Старцева // Российский семейный врач. - 2018. - Т. 22. - № 3. - С. 23-27.3.Бизунок Н.А. Противовирусные средства / Н.А. Бизунок, А.В. Гайдук. - Минск: БГМУ, 2016. - 52 с.4.Зверев В.В. 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