Bulletin of Semashko National Research Institute of Public HealthBulletin of Semashko National Research Institute of Public Health2415-84102415-8429FSSBI «N.A. Semashko National Research Institute of Public Health»1513Научная статьяDYNAMICS OF THE GENETIC BURDEN OF PUBLIC HEALTH DUE TO CONGENITAL DEVELOPMENTAL ANOMALIES, DEFORMITIES AND CHROMOSOMAL ABNORMALITIES IN THE CONSTITUENT ENTITIES OF THE RUSSIAN FEDERATION FOR 2013-2019MalakhovaA. Ralexmalakhova@gmail.comVasilievaT. Pvasileva_tp@mail.ruAleksandrovaO. Yualexandrovaoyu@nriph.ruZinchenkoR. Arenazinchenko@mail.ruN.A. Semashko National Research Institute of Public Health, Moscow, Russian FederationV.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ivanovo, Russian FederationN.P. Bochkov Medical Genetic Research Center, Moscow, Russian Federation151220211162308042022Copyright © 2021,2021Congenital malformations, deformations and chromosomal abnormalities lead to either lethal or sublethal consequences. An analysis of the frequency of congenital malformations and chromosomal abnormalities can characterize the contribution of the genetic load to the state of this indicator and determine the state of the genetic health of a population of the Russian Federation. The aim of the research was to study the contribution of the genetic load at the level of populations of the constituent entities of the Russian Federation to the formation of indicators of public health and the subjective differences in its trends in recent years. The study was conducted by the method of continuous observation according to official statistics of populations of the constituent entities of the Russian Federation for 2013-2019. The results of the study showed that there are population differences in the contribution of the genetic load due to congenital malformations and chromosomal abnormalities. At the same time, it was noted that in the presence of a general pattern of formation of trends in increasing chromosomal abnormalities and congenital developmental abnormalities in all the constituent entities of the Russian Federation, there are significant regional differences in the rate of growth of the indicator for this class, especially in the dynamics of recent years, which must be taken into account when planning measures to improve public health including its genetic determinants.public healthgenetic burdencongenital malformations and chromosomal abnormalitiestrendsthe constituent entities of the Russian Federationобщественное здоровьегенетический грузврождённые аномалии развития и хромосомные нарушениятрендысубъекты России1.Muller H.J. Our load of mutations / H.J. Muller // American Journal of Human Genetics. - 1950. - Том 2. - No 2. - С. 111-176.2.Полунина Н.В. Частота врожденных аномалий как составляющая показателя здоровья детского населения региона / Н.В. Полунина, А.Ю. Разумовский, В.А. Саввина с соавт. // Российский вестник перинатологии и педи-атрии. - 2014. - Т. 59. - No 5. - С. 47-51.3.Общая заболеваемость всего населения России в 2014 году. Статистические материалы. Часть II. - Москва, 2015.4.Общая заболеваемость всего населения России в 2015 году. Статистические материалы. Часть II. - Москва, 2016.5.Общая заболеваемость всего населения России в 2016 году. Статистические материалы. Часть II. - Москва, 2017.6.Общая заболеваемость всего населения России в 2017 году. Статистические материалы. Часть II. - Москва, 2018.7.Общая заболеваемость всего населения России в 2018 году. Статистические материалы. Часть II. - Москва, 2019.8.Общая заболеваемость всего населения России в 2019 году. Статистические материалы. Часть II. - Москва, 2020.