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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.1d1" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher">Bulletin of Semashko National Research Institute of Public Health</journal-id><journal-title-group><journal-title>Bulletin of Semashko National Research Institute of Public Health</journal-title></journal-title-group><issn publication-format="print">2415-8410</issn><issn publication-format="electronic">2415-8429</issn><publisher><publisher-name>FSSBI «N.A. Semashko National Research Institute of Public Health»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">2744</article-id><article-id pub-id-type="doi">10.25742/NRIPH.2024.02.004</article-id><article-categories><subj-group subj-group-type="heading"><subject>Научная статья</subject></subj-group></article-categories><title-group><article-title>Organizational ways to increase the effectiveness of rehabilitation measures with botulinum toxin</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Kizeev</surname><given-names>Mihail V.</given-names></name><email>m.kizeev@nriph.ru</email><uri content-type="orcid">https://orcid.org/0000-0002-0293-8372</uri><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Bodunov</surname><given-names>Aleksandr V.</given-names></name><email>a.v.bodunov@gmail.com</email><uri content-type="orcid">https://orcid.org/0009-0008-3367-6046</uri><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Nezhkina</surname><given-names>Natal`ya N.</given-names></name><email>natanezh@mail.com</email><uri content-type="orcid">https://orcid.org/0000-0002-3731-130X</uri><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Novikov</surname><given-names>Aleksandr E.</given-names></name><email>anovikov52@bmail.ru</email><uri content-type="orcid">https://orcid.org/0000-0003-0561-1161</uri><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Golubeva</surname><given-names>Galina A.</given-names></name><email>golybevagalia@gmail.com</email><uri content-type="orcid">https://orcid.org/0009-0007-3486-798X</uri><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Kulikova</surname><given-names>Yuliya A.</given-names></name><email>kulikova_sr@mail.ru</email><uri content-type="orcid">https://orcid.org/0009-0006-6356-6716</uri><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff id="aff-1">N. A. Semashko National Research Institute of Public Health</aff><aff id="aff-2">6Federal State Budgetary Healthcare Institution Reshma Medical Center of the Federal Medical Biological Agency of Russia</aff><aff id="aff-3">Federal State Budgetary Educational Institution of Higher Education «Ivanovo State Medical Academy» of the Ministry of Healthcare of the Russian Federation (FSBEI HE IvSMA MOH Russia)</aff><aff id="aff-4">Federal State Budgetary Healthcare Institution Reshma Medical Center of the Federal Medical Biological Agency of Russia</aff><pub-date date-type="epub" iso-8601-date="2024-06-04" publication-format="electronic"><day>04</day><month>06</month><year>2024</year></pub-date><issue>2</issue><fpage>25</fpage><lpage>29</lpage><history><pub-date date-type="received" iso-8601-date="2025-04-29"><day>29</day><month>04</month><year>2025</year></pub-date></history><permissions><copyright-statement>Copyright © 2025,</copyright-statement><copyright-year>2025</copyright-year></permissions><abstract>&lt;p&gt;One of the common movement disorders leading to limitation of life activity is spasticity. Medical rehabilitation plays a critical role in treating a patient's spasticity. The article presents an assessment of the organizational model of the sequence of rehabilitation measures using botulinum toxin type A using the example of the Federal State Budgetary Institution Reshma medical center of the FMBA of Russia. A comparative analysis of case histories of patients with spasticity in the arm who received injections of botulinum toxin type A in a 24-hour hospital with a profile of medical rehabilitation and a day hospital with a profile of neurology for 2022 and the first half of 2023 was carried out. It was determined that the organizational model of the sequence of rehabilitation activities using botulinum toxin type A at the Federal State Budgetary Institution Reshma medical center of the FMBA of Russia is a flexible system that can take into account the individual characteristics of each patient before his admission to the second stage of rehabilitation measures. Botulinum toxin injections can be used both before the second stage of rehabilitation and during the second stage of rehabilitation measures.&lt;/p&gt;</abstract><kwd-group xml:lang="en"><kwd>public health</kwd><kwd>organizational structure</kwd><kwd>medical rehabilitation</kwd><kwd>botulinum toxin</kwd><kwd>spasticity</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>общественное здоровье</kwd><kwd>организационная структура</kwd><kwd>медицинская реабилитация</kwd><kwd>ботулинический токсин</kwd><kwd>спастичность</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Ivanova G.E., Mel`nikova E.V., Belkin A.A., Belyaev A.F., Bodrova R.A., Bujlova T.V., Mal`ceva M.N., MishinaI .E., Prokopenko S.V., Sarana A.M., Staxovskaya L.V., Xasanova D.R., Cykunov M.B., Shamalov N.A., Suvorov A.Yu., Shmonin A.A. How to organize medical rehabilitation? Bulletin of Rehabilitation Medicine. [Vestnik vosstanovitel`noj mediciny]. 2018;2(84):2—12 (in Russian).</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation></mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Gimigliano F, NegriniS. The World Health Organization «Rehabilitation 2030: a call for action». Eur J Phys Rehabil Med. 2017;53(2):155—168. doi: 10.23736/S1973-9087.17.04746—3</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation></mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Rivelis Y, Zafar N, MoriceK. Spasticity. In: StatPearls. Treasure Island (FL): StatPearls Publishing; August 8, 2023.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation></mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Chang E, Ghosh N, Yanni D, Lee S, Alexandru D, MozaffarT. A Review of Spasticity Treatments: Pharmacological and Interventional Approaches. Crit Rev Phys Rehabil Med. 2013;25(1—2):11—22. doi: 10.1615/CritRevPhysRehabilMed.2013007945</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation></mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Bochkezanian V, Newton RU, Trajano GS, Blazevich AJ. Effects of Neuromuscular Electrical Stimulation in People with Spinal Cord Injury. Med Sci Sports Exerc. 2018;50(9):1733—1739. doi: 10.1249/MSS.0000000000001637</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation></mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Emos MC, AgarwalS. Neuroanatomy, Upper Motor Neuron Lesion. In: StatPearls. Treasure Island (FL): StatPearls Publishing; August 14, 2023.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation></mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Martino G, Ivanenko Y, Serrao M, et al. Locomotor coordination in patients with Hereditary Spastic Paraplegia. J Electromyogr Kinesiol. 2019;(45):61—69. doi: 10.1016/j.jelekin.2019.02.006</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation></mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Marsden J, Stevenson V, JarrettL. Treatment of spasticity. Handb Clin Neurol. 2023;(196):497—521. doi: 10.1016/B978-0-323-98817-9.00010—7</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation></mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Khasanova D.R., Agafonova N.V., Starostina G.Kh., Krylova L.V. Post-stroke spasticity. Consilium Medicum. [Consilium Medicum]. 2016;18(2):31—36 (in Russian).</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>10.Wissel J, Ri S, KiviA. Early versus late injections of Botulinumtoxin type A in post-stroke spastic movement disorder: A literature review. Toxicon. 2023;(229):107150. doi: 10.1016/j.toxicon.2023.107150</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation></mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Santamato A. Safety and efficacy of incobotulinumtoxinA as a potential treatment for poststroke spasticity. Neuropsychiatr Dis Treat. 2016;(12):251—263. doi: 10.2147/NDT.S86978</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation></mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Elovic EP, Munin MC, Kaňovský P, Hanschmann A, Hiersemenzel R, MarciniakC. Randomized, placebo-controlled trial of incobotulinumtoxina for upper-limb post-stroke spasticity [published correction appears in Muscle Nerve. 2016 Jun;54(1):170]. Muscle Nerve. 2016;53(3):415—421. doi: 10.1002/mus.24776</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation></mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Antipenko E.A., Gustov A.V. Possibilities and prospects for the use of botulinum toxin in neurological practice. Modern Technologies in Medicine. [Sovremennye tehnologii v medicine]. 2011;(1):102—104 (in Russian).</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation></mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Ghroubi S, Alila S, Elleuch W, Ayed HB, Mhiri C, Elleuch MH. Efficacy of botulinum toxin A for the treatment of hemiparesis in adults with chronic upper limb spasticity. Pan Afr MedJ. 2020;(35):55. doi:10.11604/pamj.2020.35.55.16091</mixed-citation></ref></ref-list></back></article>
