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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.1d1" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher">Bulletin of Semashko National Research Institute of Public Health</journal-id><journal-title-group><journal-title>Bulletin of Semashko National Research Institute of Public Health</journal-title></journal-title-group><issn publication-format="print">2415-8410</issn><issn publication-format="electronic">2415-8429</issn><publisher><publisher-name>FSSBI «N.A. Semashko National Research Institute of Public Health»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">2770</article-id><article-id pub-id-type="doi">10.25742/NRIPH.2023.03.005</article-id><article-categories><subj-group subj-group-type="heading"><subject>Обзорная статья</subject></subj-group></article-categories><title-group><article-title>Efficacy of various tb screening methods in vulnerable groups (analytical review)</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Zagdyn</surname><given-names>Zinaida M.</given-names></name><email>dinmetyan@mail.ru</email><uri content-type="orcid">https://orcid.org/0000-0003-1149-5400</uri><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Kobesov</surname><given-names>Nikolay V.</given-names></name><email>kobesovn@mail.ru</email><uri content-type="orcid">https://orcid.org/0000-0002-9833-5700</uri><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Dmitrieva</surname><given-names>Mariya P.</given-names></name><email>masha.dmitrieva@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Pechenkin</surname><given-names>Anatoliy V.</given-names></name><email>a.pechenkin@pharmline.ru</email><uri content-type="orcid">https://orcid.org/0009-0006-9821-3566</uri><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff id="aff-1">N. A. Semashko National Research Institute of Public Health</aff><aff id="aff-2">Republic Clinical Center of Pthisiopulmonology of Ministry of Health Care of Republic of North Ossetia-Alania</aff><aff id="aff-3">Saint-Petersburg State Budgetary Health Care Facility “City antituberculous dispensary”</aff><pub-date date-type="epub" iso-8601-date="2023-05-26" publication-format="electronic"><day>26</day><month>05</month><year>2023</year></pub-date><issue>3</issue><history><pub-date date-type="received" iso-8601-date="2025-05-05"><day>05</day><month>05</month><year>2025</year></pub-date></history><permissions><copyright-statement>Copyright © 2025,</copyright-statement><copyright-year>2025</copyright-year></permissions><abstract>&lt;p&gt;One of the fundamental principles of public health is the collaboration of prevention and treatment of diseases, especially socially significant ones, including infections, such as TB. Preventive measures to reduce the TB spread include its early detection (screening), among key risk groups too. The study aim, provided by using information-analytical and statistical methods, based on own materials, national and foreign publications, data obtained from federal statistical observation forms, is to know the effectiveness of various TB and LTBI screening methods, among vulnerable groups. The study results show that in Russia, along with improvement in the epidemic situation, periodic CXR examinations continue to be the main TB screening method. Effective and modern TB screening methods are used extremely rarely: MGM (6,2%), IGRA-tests for LTBI screening among key risk groups are used non-systemically, mainly among children, along with national ART. Meanwhile, with equal rates of population screening coverage and share of new TB cases found by screening, its detection rate in regions with a high TB incidence is significantly prevailing in regions with a low once (95,0% CI: -0,12  -3,11, p0,02). The obtained data indicate the need for a differentiated approach to provide TB screening measures: in regions with a high TB incidence, to maintain mass CXR screening; in areas with low incidence rates, active TB screening should be carried out only among vulnerable groups, including usage of MGM, ATR and IGRA-tests for LTBI screening, and passive TB screening should be organized among those who seek medical care.&lt;br /&gt;&lt;br /&gt;&lt;/p&gt;</abstract><kwd-group xml:lang="en"><kwd>tuberculosis</kwd><kwd>vulnerable groups</kwd><kwd>LTBI</kwd><kwd>screening</kwd><kwd>IGRA-tests</kwd><kwd>ATR</kwd><kwd>efficacy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>туберкулез</kwd><kwd>уязвимые группы</kwd><kwd>ЛТИ</kwd><kwd>скрининг</kwd><kwd>IGRA-тесты</kwd><kwd>АТR</kwd><kwd>эффективность</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Bayanova N.A., Puzhalin Ya.D., Mamedov V.G. 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