Bulletin of Semashko National Research Institute of Public HealthBulletin of Semashko National Research Institute of Public Health2415-84102415-8429FSSBI «N.A. Semashko National Research Institute of Public Health»291910.69541/NRIPH.2025.02.027Научная статьяPhysiological aspects of the use of gravidan in the treatment of malaria in the USSR in the 1930sBatoevSergey D.sbatoev@list.ruKrylovNikolay N.nnkrylov01@yandex.ruKarpenkoIgor V.karpenko.iv.@bk.ruIvanishkinaYulia V.uyli77@mail.ruI. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation20072025214815201082025Copyright © 2025,2025The spread of malaria all over the world, the millions of victims it claimed, attracted the great attention of scientists from different countries. The deterioration of environmental and socio-economic conditions after the First World War and the Civil War significantly affected the spread of malaria. The late 20s and early 30s of the 20th century were marked by various biomedical experiments, including attempts to create a universal drug that increases overall life potential and quickly restores human performance and activity. An attempt was made to treat such a dangerous climate-dependent disease as malaria with drugs whose pharmacological action would not have side effects. One of these areas was the creation and experimental study, and then mass production, and the further use of gravidan in the treatment of malaria, which was of urgent importance at that time. Of course, today the use of this method looks exotic and unscientific, but this is a historical fact that took place in Russian medicine. The historical and medical aspect of its use in the treatment of malaria, both as monotherapy and in combination with specific antimalarial drugs, gave hope for some success and was of priority importance not only therapeutically, but economically. Thus, the drug gravidan, created in the USSR, entered the history of science as the first hormonal drug capable of activating the internal defense mechanisms of the human body, and thereby supporting its physical and cognitive well-being.history of medicine, physiology, experiment, gravidan, malaria.история медицины, физиология, эксперимент, гравидан, малярия.1.Горелова Л. Е. Из истории борьбы с малярией. Русский медицинский журнал. 2009;(7):503.2.Остроглазов В. Миф о гравидане. К предистории Московской областной ПБ. №5. Независимый психиатрический журнал. 2008;(3):16.3.Сойкина А. Гравидан: история лекарства, которое считали панацеей, но забыли. Новая аптека. 2023;(3):98—103.4.Лысков А. Гравидан Алексея Замкова. Уральский следопыт. 2018;(07):17—19.