Bulletin of Semashko National Research Institute of Public HealthBulletin of Semashko National Research Institute of Public Health2415-84102415-8429FSSBI «N.A. Semashko National Research Institute of Public Health»294510.69541/NRIPH.2025.03.013Научная статьяRisk factors prevalence in patients with chronic critical limb ischemia and comorbidity of ischemic cardiovascular diseases with indications for multivessel revascularizationGoloshchapov-AksenovRoman Sergeevichgoloschapovaksenovr@gmail.comRukodaynyyOleg Vladimirovichrukodaynyy_ov@pfur.ruKoledinskyAnton Gennad'evichkard.gkb79@mail.ruBaginSergey Andreevichsabg@@gmail.comVolkovPavel Sergeevichxirulk@yandex.ruGalstyanKarina Pavlovnaskp63@mail.ruPeoples' Friendship University of Russia named after Patris Lumumba (RUDN University), Moscow, Russian FederationPrivate Medical Center «Medical On Group-Odintsovo», Moscow Region, Russian FederationLLC FMC (Family Medicine Center) Medica, Saint Petersburg, Russian Federation260920253859130092025Copyright © 2025,2025Chronic critical limb ischemia (CCLI) is an unfavorable process in patients with obliterating diseases of the arteries of the lower extremities and is accompanied by a high risk of fatal outcomes, limb amputation and disability. Objective. To analyze the prevalence of risk factors in patients with CCLI and comorbidity of ischemic cardiovascular diseases (CVD) with indications for multivessel revascularization, to evaluate their prognostic significance and information content. Materials and methods. A retrospective multicenter research (2018—2024) was performed, big data on medical services in patients (n=782): the group А (n = 657) — patients with CCLI 3—4 st., average age — 74±3.1 years, men 72.8%. The group В (n=125) — patients without CVD and risk factors CVD, average age 44±1.05 years, men — 65.6%. The anamnestic (≥12 months before the development of CCLI) prevalence, information content and prognostic significance of smoking, alcohol consumption, intermittent claudication, hypertension, diabetes, hypercholesterolemia, hyperhomocysteinemia, chronic heart failure, history of myocardial infarction, level of daily physical activity, compliance to medication, self-monitoring of hemodynamic parameters, primary care of cardiologist or cardiovascular surgeon were studied. In patients of group B, the risks of developing CCLI within 12 months in the absence of intermittent claudication were research. The analytical period is 12 months. The following methods: content analysis, statistical, systematization, comparative analysis, mathematical. Results. In patients of group А established a high prevalence and significant prognostic significance and informativeness of Kullback for most of the risk factors of CLLI. In patients of group B, there was no risk of developing CCILI. Conclusion. The results of the research determine the need for personalized multifactorial analysis of the CVD at the primary health care level in all patients over 50 years old for correct the risk factors of CCLI.chronic critical limb ischemiaischemic cardiovascular diseasescomorbidityrisk factorspredictive valueinformation contentmultivessel revascularization.хроническая критическая ишемия нижних конечностейишемические сердечно-сосудистые заболеваниякоморбидностьфакторы рискапрогностическая значимостьинформативностьмногососудистая реваскуляризация.[Conte M., Bradbury A., Kolh P. Global vascular guidelines on the management of chronic limb-threatening ischemia. 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