Bulletin of Semashko National Research Institute of Public HealthBulletin of Semashko National Research Institute of Public Health2415-84102415-8429FSSBI «N.A. Semashko National Research Institute of Public Health»294710.69541/NRIPH.2025.03.015Научная статьяModels of regional healthcare system functioning under different types of global challengesOrlovSergey Aleksandrovichorlovsergio@mail.ruN. A. Semashko National Research Institute of Public Health, 105064, Moscow, Russian Federation2609202539610330092025Copyright © 2025,2025The article presents models for the functioning of a regional healthcare system under emergency conditions, using the examples of biological threats and man-made disasters. The models take into account the interaction between emergency medical services, hospitals, outpatient clinics, and a coordination center, enabling the identification of problematic areas in the organization of medical care delivery processes. The article provides a set of quantitative metrics that allow for the assessment of throughput capacity, resource availability, and the flexibility of the healthcare system. The obtained results demonstrate the effectiveness of a systems-based approach to the management of medical resources in emergency situations and can serve as a foundation for the development of software products for healthcare monitoring and planning.biological challenges, modeling, regional healthcare system, healthcare resources, man-made disasters, emergencies.биологические вызовы, моделирование, региональная система здравоохранения, ресурсы здравоохранения, техногенные катастрофы, чрезвычайные ситуации.[Орлов С. А., Александрова О. Ю. Современные проблемы оценки готовности национальных систем здравоохранения к биологическим угрозам (литературный обзор). Медико-биологические и социально-психологические проблемы безопасности в чрезвычайных ситуациях. 2024;(1):108—117. DOI: 10.25016/2541-7487-2024-0-1-108-117][Aminizadeh M, Farrokhi M, Ebadi A, Masoumi G, Kolivand P, Khankeh H. Hospital Preparedness Challenges in Biological Disasters: A Qualitative Study. Disaster Med Public Health Prep. 2022;16(3):956—960. DOI: 10.1017/dmp.2020.434][Göransson Nyberg A, Stricklin D, Sellström Å. Mass casualties and health care following the release of toxic chemicals or radioactive material — contribution of modern biotechnology. Int J Environ Res Public Health. 2011;8(12):4521—4549. DOI: 10.3390/ijerph8124521][Простакишин Г. П., Сарманаев С. Х., Аветисов Г. М. Основные недостатки и нерешенные вопросы ликвидации медико-санитарных последствий химических чрезвычайных ситуаций. Медицина катастроф. 2020;(4):28—32. DOI: 10.33266/2070-1004-2020-4-28-32][Gozlan A, Abuhasira R, Dreiher J, et al. October 7th 2023 mass casualty incident in southern Israel: lessons for emergency preparedness and management. Isr J Health Policy Res. 2024;13(1):67. DOI: 10.1186/s13584-024-00651-7][Cantor D, Swartz J, Roberts B, et al. Understanding the health needs of internally displaced persons: A scoping review. J Migr Health. 2021;(4):100071. DOI: 10.1016/j.jmh.2021.100071][Hasan MK, Nasrullah SM, Quattrocchi A, Arcos González P, Castro Delgado R. Hospital Surge Capacity Preparedness in Disasters and Emergencies: Protocol for a Systematic Review. Int J Environ Res Public Health. 2022;19(20):13437. DOI: 10.3390/ijerph192013437][Meyer D, Bishai D, Ravi SJ, et al. A checklist to improve health system resilience to infectious disease outbreaks and natural hazards. BMJ Glob Health. 2020;5(8):e002429. DOI: 10.1136/bmjgh-2020-002429][Emami SG, Lorenzoni V, Turchetti G. Towards Resilient Healthcare Systems: A Framework for Crisis Management. Int J Environ Res Public Health. 2024;21(3):286. DOI: 10.3390/ijerph21030286][Laker LF, Torabi E, France DJ, et al. Understanding Emergency Care Delivery Through Computer Simulation Modeling. Acad Emerg Med. 2018;25(2):116—127. DOI: 10.1111/acem.13272]