Bulletin of Semashko National Research Institute of Public HealthBulletin of Semashko National Research Institute of Public Health2415-84102415-8429FSSBI «N.A. Semashko National Research Institute of Public Health»303710.25742/NRIPH.2023.04.022Научная статьяDevelopment of ideas on the mechanisms of regulation of potassium homeostasis in the second half of the 20th century (review)PanovaAnastasia S.passad.nsk@gmail.comSubotyalovMikhail A.subotyalov@yandex.ruSorokinaTatiana S.sorokina-ts@rudn.ruState Research Center of Virology and Biotechnology «Vector», Koltsovo, Novosibirsk region, Russian FederationNovosibirsk State Pedagogical University, Novosibirsk, Russian FederationNovosibirsk State University, Novosibirsk, Russian FederationRUDN University, Moscow, Russian Federation.15122023413213620102025Copyright © 2023,2023Since the second half of the 20th century, research on the ion-regulating function of the kidneys, in particular the mechanisms of regulation of such ions as sodium, potassium and magnesium, has become widespread throughout the world. This review is devoted to the history of studying the mechanisms of regulation of potassium homeostasis in the second half of the previous century. When preparing the review, publications of foreign and domestic researchers included in the PubMed and eLIBRARY databases were studied. The existence of tubular secretion of potassium has been proven. Later, the hypothesis of direct exchange of cations in the distal tubules was put forward and experimentally proved. In the 1970s the renal and extrarenal mechanisms of tubular potassium transport have been described in detail. At the same time, domestic researchers proposed and experimentally confirmed the hypothesis of the existence of a reflex system for the regulation of potassium homeostasis; the reflex and hormonal mechanisms of regulation, as well as ontogenetic features of potassium transport, were studied. Thus, by the end of the 20th century, a clear picture of the regulation of potassium homeostasis was formed both at the level of the whole organism and its individual structures.ion regulation, potassium homeostasis, excretion, secretion, potassium, ionsионная регуляция, гомеостаз калия, экскреция, секреция, калий, ионы1.Mudge G. H., Foulks J., Gilman A. The renal excretion of potassium. Proc Soc Exp Biol Med. 1948;67(4):545—547. Doi: 10.3181/00379727-67-16369p.2.Baldwin D., Kahana E. M., Clarke R. W. Renal excretion of sodium and potassium in the dog. Am J Physiol. 1950;162(3):655—664. Doi: 10.1152/ajplegacy.1950.162.3.655.3.Berliner R. W., Kennedy T. J. Jr., Hilton J. G. Renal mechanisms for excretion of potassium. Am J Physiol. 1950;162(2):348—367. Doi: 10.1152/ajplegacy.1950.162.2.348.4.Pitts R. F., Alexander R. S. The nature of the renal tubular mechanism for acidifying the urine. Am J Physiol. 1945;144(2):239—254.5.Pitts R. F., Lotspeich W. D. Bicarbonate and the renal regulation of acid base balance. Am J Physiol. 1946;147(1):138—154. Doi: 10.1152/ajplegacy.1946.147.1.138.6.Orloff J., Davidson D. G. The mechanism of potassium excretion in the chicken. J Clin Invest. 1959;38(1. Part 1):21—30. Doi: 10.1172/JCI103790.7.Giebisch G. Some reflections on the mechanism of renal tubular potassium transport. Yale J Biol Med. 1975;48(4):315—336.8.Suki W. N. Disposition and regulation of body potassium: an overview. Am J Med Sci. 1976;272(1):31—41. Doi: 10.1097/00000441-197607000-00004.9.Финкинштейн Я. Д., Айзман Р. И., Тернер А. Я., Пантюхин И. В. Рефлекторный механизм регуляции калиевого гомеостаза. Российский физиологический журнал им. И. М. Сеченова. 1973;59(9):1429—1436.10.Rabinowitz L., Aizman R. I. The central nervous system in potassium homeostasis. Frontiers in Neuroendocrinology. 1993;14(1):1—26. Doi: 10.1006/frne.1993.1001.11.Забелло И. Н., Курдубан Л. И., Финкинштейн Я. Д. Рефлекторная регуляция экскреции калия в постнатальном онтогенезе собак. Журнал эволюционной биохимии и физиологии. 1982;(18):477—481.12.Aizman R. I., Celsi G., Grahnquist L., Wang Z. M., Finkel Y., Aperia A. Ontogeny of K+ transport in rat distal colon. Am J Physiol. 1996;271(2 Pt 2):G268—G274. Doi: 10.1152/ajpgi.1996.271.2.G268.13.Aizman R., Brismar H., Celsi G. Nitric oxide inhibits potassium transport in the rat distal colon. Am J Physiol. 1999;276(1):G146—G154. Doi: 10.1152/ajpgi.1999.276.1.G146.14.Aperia A., Cheng X. -J., Fisone G., Aizman O., Aizman R., Levenson R., Greengard P. PKA-mediated phosphorylation and inhibition of Na+-K+-ATPase in response to β-adrenergic hormone. Am J Physiol. 1997;273(3 Pt 1):C893—C901. Doi: 10.1152/ajpcell.1997.273.3.C893.15.Aizman R., Gerasev A., Taranov A. Hormonal mechanisms of potassium homeostasis regulation. Renal physiology and biochemistry. 1992;(3—4):203.