<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.1d1" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher">Bulletin of Semashko National Research Institute of Public Health</journal-id><journal-title-group><journal-title>Bulletin of Semashko National Research Institute of Public Health</journal-title></journal-title-group><issn publication-format="print">2415-8410</issn><issn publication-format="electronic">2415-8429</issn><publisher><publisher-name>FSSBI «N.A. Semashko National Research Institute of Public Health»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">3075</article-id><article-id pub-id-type="doi">10.69541/NRIPH.2025.04.017</article-id><article-categories><subj-group subj-group-type="heading"><subject>Научная статья</subject></subj-group></article-categories><title-group><article-title>Results of the evaluation of the effectiveness of the implementation of a comprehensive organizational technology for the early detection of malignant neoplasms in children and the routing of children in the regions of the Russian Federation</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Kirgizov</surname><given-names>Kirill Igorevich</given-names></name><bio></bio><email>k.kirgizov@ronc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Omelyanovsky</surname><given-names>Vitaly Vladimirovich</given-names></name><bio></bio><email>office@rosmedex.ru</email><xref ref-type="aff" rid="aff-2"/><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Varfolomeeva</surname><given-names>Svetlana Rafaelevna</given-names></name><bio></bio><email>s.varfolomeeva@ronc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff id="aff-1">N. N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation, Moscow, Russian Federation</aff><aff id="aff-2">Center for Expertise and Quality Control of Medical Care of the Ministry of Health of the Russian Federation</aff><aff id="aff-3">Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation</aff><pub-date date-type="epub" iso-8601-date="2025-11-29" publication-format="electronic"><day>29</day><month>11</month><year>2025</year></pub-date><issue>4</issue><fpage>106</fpage><lpage>113</lpage><history><pub-date date-type="received" iso-8601-date="2025-12-01"><day>01</day><month>12</month><year>2025</year></pub-date></history><permissions><copyright-statement>Copyright © 2025,</copyright-statement><copyright-year>2025</copyright-year></permissions><abstract>A retrospective analytical study was conducted to assess the impact of the implemented comprehensive organizational technology on the indicators of detection (incidence) and in-hospital mortality from oncological diseases in children across the regions. Primary data were obtained through a depersonalized extraction from the hospital-based cancer registry. The inclusion criteria for the analysis were: a diagnosis of an oncological disease (solid malignant neoplasms, benign neoplasms, hemoblastoses), patient age (children), and belonging to the regions supervised by this center and included in the organizational experiment for technology implementation. The total analyzed sample size comprised 4,952 records for the period from 2018 to 2024. The results of the implementation of the comprehensive organizational technology in the constituent entities of the Russian Federation indicate its medical effectiveness, which is manifested by statistically significant improvements in a number of key indicators. First, a reliable increase in the growth rates of detection (primary incidence) was recorded: in 2023 and 2024 relative to the baseline year 2019, the increase was 159.13% and 187.55%, respectively, which significantly exceeds the pre-implementation period indicator for 2020 (37.46%; p=0.0017). Second, a significant increase in the rate of reduction of in-hospital mortality from childhood cancer was noted—in 2024, the reduction reached 27.78% compared to 18.84% in 2020 (p=0.0397). Furthermore, the implementation of the technology contributed to improved accessibility of medical care: the waiting times for hospitalization of children with malignant neoplasms decreased from 7±1.2 days in 2019 to 3±0.8 days in 2023. An increase in the volume of high-tech care was also observed, as illustrated by the rise in the number of hematopoietic stem cell transplantations from 728 in 2019 to 858 in 2023.</abstract><kwd-group xml:lang="en"><kwd>organizational technology, medical efficiency, organizational experiment, routing, early detection, pediatric oncology, malignant neoplasms</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>организационная технология, медицинская эффективность, организационный эксперимент, маршрутизация, раннее выявление, детская онкология, злокачественные новообразования</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Haimi M., Peretz Nahum M., Ben Arush M. W. Delay in diagnosis of children with cancer: a retrospective study of 315 children. Pediatr. Hematol. Oncol. 2004;21(1):37—48.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Buckle G. C., Collins J. P., Sumba P. O., Nakalema B., Omenah D., Stiffler K., et al. Factors influencing time to diagnosis and initiation of treatment of endemic Burkitt Lymphoma among children in Uganda and western Kenya: a cross-sectional survey. Infect. Agent. Cancer. 2013;8(1):36. DOI: 10.1186/1750-9378-8-36</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Handayani K., Sitaresmi M. N., Supriyadi E., Widjajanto P. H., Susilawati D., Njuguna F., et al. Delays in diagnosis and treatment of childhood cancer in Indonesia. Pediatr. Blood Cancer. 2016;63(12):2189—2196. DOI: 10.1002/pbc.26174</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Baker J. M., To T., Beyene J., Zagorski B., Greenberg M. L., Sung L. Influence of length of time to diagnosis and treatment on the survival of children with acute lymphoblastic leukemia: a population-based study. Leuk. Res. 2014;38(2):204—209. DOI: 10.1016/j.leukres.2013.11.014</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>A new clinical guideline from the Royal College of Paediatrics and Child Health with a national awareness campaign accelerates brain tumor diagnosis in UK children—»HeadSmart: Be Brain Tumour Aware». Neuro. Oncol. 2016;18(3):445—454. DOI: 10.1093/neuonc/nov187</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Moreira D. C., Gajjar A., Patay Z., Boop F. A., Chiang J., Merchant T. E., et al. Creation of a successful multidisciplinary course in pediatric neuro-oncology with a systematic approach to curriculum development. Cancer. 2021;127(7):1126—1133. DOI: 10.1002/cncr.33350</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Shanmugavadivel D., Liu J. F., Ball-Gamble A., Polanco A., Vedhara K., Walker D., et al. The Childhood Cancer Diagnosis (CCD) Study: a UK observational study to describe referral pathways and quantify diagnostic intervals in children and young people with cancer. BMJ Open. 2022;12(2):e058744. DOI: 10.1136/bmjopen-2021-058744</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Stubbings S., Robb K., Waller J., Ramirez A., Austoker J., Macleod U., et al. Development of a measurement tool to assess public awareness of cancer. Br. J. Cancer. 2009;101 Suppl 2(Suppl 2):S13-7. DOI: 10.1038/sj.bjc.6605385</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Chukwu B. F., Ezenwosu O. U., Ikefuna A. N., Emodi I. J. Diagnostic delay in pediatric cancer in Enugu, Nigeria: a prospective study. Pediatr. Hematol. Oncol. 2015;32(2):164—171. DOI: 10.3109/08880018.2014.957368</mixed-citation></ref></ref-list></back></article>
