The paper presents an analysis of morbidity from the external causes of the population in the Chelyabinsk region. More than 12% of residents turned to medical organizations for help due to external causes. One in four cases (25,4%) was registered in children, 19,0% of cases were in persons older than working age. In the context of the municipal formations of the Chelyabinsk region, a significant resonance in the level of primary incidence of the population from external causes has been revealed, which indicates the need to develop targeted measures aimed at improving the routing of victims. Given that external causes are injuries that require, as a rule, emergency and urgent medical care, it is necessary to organize traumatic centers, burn centers and acute poisoning centers, taking into account the stable endemic situation in various municipalities, the material and technical base of medical organizations and the climate-geographical features of the region.