The first part of the article is devoted to decentralized types for regulating pharmaceutical activities in medieval Europe. Despite the disunity of cities in the 12–15th centuries, they introduced similar regulatory norms, going back to the Sicilian Constitutions and the Edict of Salerno of Emperor Frederick II. In the cities of central and northern Europe, the implementation of regulatory norms was based on the personal responsibility of pharmacists to the authorities. In the southern territories, corporate governance through guilds was more commonly used. This message shows the features, similarities and differences of such types of regulation as pharmacy regulations, oaths of apothecary, apothecaries’ service letters and privileges.

apothecary, pharmacy, regulation, oath of apothecaries, Middle Ages.