Inpatient palliative care is primarily needed by adult patients over the age of 60 who have chronic diseases and a polymorbid background. Realizing the needs of patients and solving their urgent problems in inpatient settings is the main task of nurses. The study conducted in 2021—2022 confirmed the importance of the professional activities of nurses in solving problems and needs of palliative patients. The special conditions of professional activity for nurses are the severity of the patients' condition, since most often in their practice they encounter patients with various forms of cancer (85.0%, CI 81.4—88.6), severe irreversible consequences of cerebrovascular accidents (58.6%, CI 53.8—63.4), degenerative diseases of the nervous system in the late stages of the disease (40.2%, CI 35.4—45.0). Nurses in the professional field often face such groups of problems of palliative patients in inpatient settings, as pain syndrome (85.5%), manifestations of digestive disorders (60.3%), respiratory disorders (55.4%), slightly less — with mental and neurological (48.2%), as well as urological problems of patients (40.4%). The frequency of occurrence of problems and symptoms in palliative patients in the professional activities of nurses is presented. The leading problems in palliative patients requiring nursing care are constipation (86.5%), nausea and vomiting (80.0%), dry mouth (70.1%), shortness of breath (79.4%), urinary incontinence (75.9%), difficulty urinating (64.5%), insomnia (77.9%), manifestations of dementia (70.4%) and depression (61.6%).