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Development of ideas on the mechanisms of regulation of potassium homeostasis in the second half of the 20th century (review)
- Authors: Panova A.S.1, Subotyalov M.A.2,3, Sorokina T.S.4
- Affiliations:
- State Research Center of Virology and Biotechnology «Vector», Koltsovo, Novosibirsk region, Russian Federation
- Novosibirsk State Pedagogical University, Novosibirsk, Russian Federation
- Novosibirsk State University, Novosibirsk, Russian Federation
- RUDN University, Moscow, Russian Federation.
- Issue: No 4 (2023)
- Pages: 132-136
- Section: Articles
- URL: https://bulleten-nriph.ru/journal/article/view/3037
- DOI: https://doi.org/10.25742/NRIPH.2023.04.022
- Cite item
Abstract
Since the second half of the 20th century, research on the ion-regulating function of the kidneys, in particular the mechanisms of regulation of such ions as sodium, potassium and magnesium, has become widespread throughout the world. This review is devoted to the history of studying the mechanisms of regulation of potassium homeostasis in the second half of the previous century. When preparing the review, publications of foreign and domestic researchers included in the PubMed and eLIBRARY databases were studied. The existence of tubular secretion of potassium has been proven. Later, the hypothesis of direct exchange of cations in the distal tubules was put forward and experimentally proved. In the 1970s the renal and extrarenal mechanisms of tubular potassium transport have been described in detail. At the same time, domestic researchers proposed and experimentally confirmed the hypothesis of the existence of a reflex system for the regulation of potassium homeostasis; the reflex and hormonal mechanisms of regulation, as well as ontogenetic features of potassium transport, were studied. Thus, by the end of the 20th century, a clear picture of the regulation of potassium homeostasis was formed both at the level of the whole organism and its individual structures.
About the authors
Anastasia S. Panova
State Research Center of Virology and Biotechnology «Vector», Koltsovo, Novosibirsk region, Russian Federation
Email: passad.nsk@gmail.com
Mikhail A. Subotyalov
Novosibirsk State Pedagogical University, Novosibirsk, Russian Federation; Novosibirsk State University, Novosibirsk, Russian Federation
Email: subotyalov@yandex.ru
Tatiana S. Sorokina
RUDN University, Moscow, Russian Federation.
Email: sorokina-ts@rudn.ru
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