The study evaluates the costs of medical treatment of patients suffering from narcological disorders in a 24-hour hospital with various diagnoses according to ICD — 10. The aim of the study is to assess some characteristics of the costs of the drug treatment used for patients with various drug-related diseases when providing them with medical care in inpatient settings, taking into account the variability of costs, the degree of their compliance with clinical recommendations, and the average cost. Materials and methods. The calculation of the characteristics of drug costs in four groups of patients with the most common diagnoses according to the profile «narcology» was made. 200 medical records of an inpatient patient — case histories (form No. 003/y) of patients who underwent treatment in the hospital of the state budgetary healthcare Institution (GBUZ) «Samara Regional Clinical Narcological Dispensary» in 2022 were analyzed. The cost variation coefficient was calculated, and the average cost values for medicines (in rubles) were compared. It is also determined what proportion of the cost of medicines falls on the drugs recommended by clinical protocols, or groups of drugs. Analytical and statistical research methods were used. Results. The average cost of medical treatment per hospitalization for all diagnoses amounted to 1969.1±157.5 rubles. with the highest costs for the treatment of withdrawal caused by opioid use (2189.7 ± 176.4 rubles) and the lowest costs for the treatment of uncomplicated withdrawal caused by alcohol use (1484.6 ±145.7 rubles). In general, for all groups of patients, the share of costs for the groups of medicines recommended in the clinical recommendations is 58.3%, which is quite low. High values of the coefficient of variation of drug costs in the studied groups were obtained from 33.2% for opioid dependence syndrome to 56.9% in the group of patients with alcohol dependence syndrome undergoing aversive treatment. The cost of medicines for the treatment of patients diagnosed with uncomplicated withdrawal caused by alcohol consumption had a significant difference from the cost of drug treatment of patients of other groups. Conclusion. Despite the high rates of the coefficient of variation of costs and the presence of statistically significant differences in the average cost of inpatient treatment of some groups of patients, it is premature to draw conclusions about the need to increase the number of clinical and statistical groups (CSG) in the profile of «narcology» with budgetary financing of the system, based on the difference in the cost of medicines. It is correct to compare the average cost values in groups with different diagnoses with comparably high levels of spending on medicines included in clinical recommendations.